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PYGB regulates the MAPK/ERK signaling pathway. A and B GO and KEGG studies revealed that PYGB exhibited associations with many metabolic pathways and signaling pathways implicated in tumorigenesis. C–E GSEA showed that PYGB was associated with multiple critical tumor-related signaling pathways, most notably the MAPK signaling pathway. F PYGB overexpression resulted in enhanced MEK and ERK phosphorylation
