Table 2.

Interacting residues between DENV-2 peptide and SH3 domain

Viral protein	Peptide	Receptor residue	DENV-2 peptide residue	Interaction dist. (Å)	Interaction type
Envelope	417–423	SER 14 [OG]	THR 6 [OG1]	3.81649	H bond
NS1	808–814	LYS 13[ N]	SER 6[ OG]	2.74	H bond
		GLN 11[ N]	PRO 7[ O]	2.62	H bond
		LYS 13[ O]	GLU 5[ N]	3.90	H bond
		TYR 10[ OH]	SER 6[ N]	3.78	H bond
	811–816	GLN 11[ N]	PRO 1[ O]	3.54	H bond
		TYR 10[ OH]	SER 3[ OG]	2.62	H bond
		ASP 9[ O]	PRO 1[ N]	3.61	H bond
		GLU 17[ OE1]	SER 3[ OG]	3.72	H bond
		SER 14[ OG]	LYS 6[ N]	2.90	H bond
NS3	1479–1485	TYR 10[ OH]	TRP 2[ O]	3.68	H bond
		TYR 10[ OH]	ASP 3[ OD1]	3.49	H bond
		SER 14[ N]	ASP 3[ OD2]	2.86	H bond
	1480–1486	ASN 30[ ND2]	TRP 1[ O]	3.68	H bond
		SER 14[ OG]	B:SER 5[ OG]	3.68	H bond
		SER 14[ OG]	PRO 6[ O]	3.86	H bond
		THR 32[ OG1]	TRP 1[ NE1]	3.52	H bond
	1894–1900	LYS 13[ NZ]	ALA 1[ O]	3.09	H bond
		ASN 30[ ND2]	ASP 6[ OD1]	3.58	H bond
NS5	2694–2700	SER 14[ OG]	VAL 4[ O]	3.89	H bond
		ASP 35[ OD2]	ARG 5[ NH1]	2.66	H bond
					Salt bridge
	3068–3074	TYR 8[ OH]	VAL 1[ N]	3.71	H bond
		TYR 10[ OH]	VAL 4[ N]	3.07	H bond
	3154–3160	ARG 16[ NH2]	ASP 1[ OD2]	3.38	H bond
					Salt bridge
		SER 14[ N]	LYS 6[ O]	2.74	H bond
		TYR 10[ OH]	PRO 7[ OXT]	2.60	H bond
		ASN 33[ OD1]	ASP 1[ N]	3.28	H bond
		GLU 17[ OE2]	LYS 6[ N]	2.67	H bond
		TYR 10[ OH]	PRO 7[ N]	3.00	H bond
		GLU 17[ OE2]	PRO 7[ N]	3.80	H bond