Table 2.
Brain region CBF with significant group differences in patients.
| Regions | Coordinates in MNI (x, y, z) | Cluster-level FWE | Peak t values | Cluster size (voxels) |
|---|---|---|---|---|
| Female patients with HAT in CSF >Healthy subjects | ||||
| MTP_L | −34, 0, −48 | p = 0.001 | 5.01 | 91 |
| ITG_L | −34, 0, −48 | 5.01 | 77 | |
| MTG_L | −34, 0, −48 | 5.01 | 71 | |
| Putamen_L | −28, 0, −6 | p = 0.001 | 4.42 | 362 |
| Amygdala_L | −28, 0, −6 | 4.42 | 35 | |
| MOFG_L | −40, 56, −8 | p = 0.001 | 4.90 | 143 |
| SOFG_L | −40, 56, −8 | 4.90 | 71 | |
| IOFG_L | −40, 56, −8 | 4.90 | 37 | |
| STP_R | 54, 16, −10 | p = 0.001 | 5.79 | 706 |
| IOFG_R | 54, 16, −10 | 5.79 | 327 | |
| Putamen_R | 54, 16, −10 | 5.79 | 273 | |
| MTP_R | 54, 16, −10 | 5.79 | 251 | |
| Insula_R | 54, 16, −10 | 5.79 | 216 | |
| TIFG_R | 54, 16, −10 | 5.79 | 59 | |
| Caudate_R | 54, 16, −10 | 5.79 | 39 | |
| Olfactory_R | 54, 16, −10 | 5.79 | 34 | |
| OIFG_R | 54, 16, −10 | 5.79 | 32 | |
| Female patients with HAT in CSF < Healthy subjects | ||||
| Precuneus_R | 26, −86, −6 | p = 0.001 | −5.42 | 817 |
| Calcarine_R | 26, −86, −6 | −5.42 | 606 | |
| Calcarine_L | 26, −86, −6 | −5.42 | 577 | |
| Lingual_R | 26, −86, −6 | −5.42 | 454 | |
| Precuneus_L | 26, −86, −6 | −5.42 | 443 | |
| Lingual_L | 26, −86, −6 | −5.42 | 189 | |
| IOG_L | 26, −86, −6 | −5.42 | 178 | |
| MOG_L | 26, −86, −6 | −5.42 | 165 | |
| IOG_R | 26, −86, −6 | −5.42 | 106 | |
| Cuneus_L | 26, −86, −6 | −5.42 | 103 | |
| Cuneus_R | 26, −86, −6 | −5.42 | 103 | |
| Fusiform_R | 26, −86, −6 | −5.42 | 95 | |
| PCG_L | 26, −86, −6 | −5.42 | 84 | |
| MOG_R | 26, −86, −6 | −5.42 | 69 | |
| MCG_R | 26, −86, −6 | −5.42 | 56 | |
| SOG_L | 26, −86, −6 | −5.42 | 55 | |
| PCG_R | 26, −86, −6 | −5.42 | 51 | |
| SOG_R | 26, −86, −6 | −5.42 | 38 | |
| Female patients with LAT in CSF > Healthy subjects | ||||
| Putamen_L | −24, 6, −2 | p = 0.001 | 5.40 | 507 |
| Caudate_L | −24, 6, −2 | 5.40 | 23 | |
| Amygdala_L | −24, 6, −2 | 5.40 | 23 | |
| Pallidum_L | −24, 6, −2 | 5.40 | 20 | |
| Female patients with LAT in CSF < Healthy subjects | ||||
| Precuneus_R | 10, −48, 50 | p = 0.001 | −4.10 | 190 |
| Female patients with HAT in CSF > Female patients with LAT in CSF | ||||
| STP_R | 46, 10, −18 | p = 0.001 | 4.63 | 276 |
| MTP_R | 46, 10, −18 | 4.63 | 81 | |
| Female patients with HAT in CSF < Female patients with LAT in CSF | ||||
| Calcarine_L | 12, −66, 26 | p = 0.001 | −4.94 | 122 |
| Precuneus_L | 12, −66, 26 | −4.94 | 121 | |
| Cuneus_L | 12, −66, 26 | −4.94 | 90 | |
| Calcarine_R | 12, −66, 26 | −4.94 | 86 | |
| Precuneus_R | 12, −66, 26 | −4.94 | 36 | |
| Male patients with HAT in CSF > Healthy subjects | ||||
| STG_L | −28, 10, −4 | p = 0.001 | 7.22 | 601 |
| Putamen_L | −28, 10, −4 | 7.22 | 455 | |
| Insula_L | −28, 10, −4 | 7.22 | 256 | |
| Amygdala_L | −28, 10, −4 | 7.22 | 160 | |
| STP_L | −28, 10, −4 | 7.22 | 149 | |
| Postcentral_L | −28, 10, −4 | 7.22 | 115 | |
| MTG_L | −28, 10, −4 | 7.22 | 102 | |
| RO_L | −28, 10, −4 | 7.22 | 74 | |
| Heschl_L | −28, 10, −4 | 7.22 | 53 | |
| MTP_L | −28, 10, −4 | 7.22 | 50 | |
| Hippocampus_L | −28, 10, −4 | 7.22 | 38 | |
| Supramarginal_L | −28, 10, −4 | 7.22 | 38 | |
| IOFG_L | −28, 10, −4 | 7.22 | 27 | |
| Male patients with HAT in CSF < Healthy subjects | ||||
| Precuneus_R | 10, −58, 26 | p = 0.001 | −5.22 | 168 |
| Calcarine_R | 10, −58, 26 | −5.22 | 35 | |
| Precuneus_L | −6, −70, 46 | p = 0.001 | −5.06 | 194 |
| Male patients with LAT in CSF > Healthy subjects | ||||
| Putamen_L | −52, −6, −4 | p = 0.001 | 5.35 | 603 |
| STG_L | −52, −6, −4 | 5.35 | 558 | |
| Insula_L | −52, −6, −4 | 5.35 | 447 | |
| RO_L | −52, −6, −4 | 5.35 | 148 | |
| Pallidum_L | −52, −6, −4 | 5.35 | 112 | |
| STP_L | −52, −6, −4 | 5.35 | 99 | |
| Amygdala_L | −52, −6, −4 | 5.35 | 78 | |
| Caudate_L | −52, −6, −4 | 5.35 | 76 | |
| OIFG_L | −52, −6, −4 | 5.35 | 73 | |
| Postcentral_L | −52, −6, −4 | 5.35 | 55 | |
| Olfactory_L | −52, −6, −4 | 5.35 | 44 | |
| Heschl_L | −52, −6, −4 | 5.35 | 39 | |
| MTG_L | −52, −6, −4 | 5.35 | 35 | |
| Hippocampus_L | −52, −6, −4 | 5.35 | 30 | |
| MTP_L | −52, −6, −4 | 5.35 | 28 | |
| Male patients with LAT in CSF < Healthy subjects | ||||
| Precuneus_R | 18, −68, 40 | p = 0.001 | −6.40 | 527 |
| SOG_R | 18, −68, 40 | −6.40 | 324 | |
| Precuneus_L | 18, −68, 40 | −6.40 | 307 | |
| MOG_R | 18, −68, 40 | −6.40 | 275 | |
| SPG_R | 18, −68, 40 | −6.40 | 270 | |
| Cuneus_R | 18, −68, 40 | −6.40 | 210 | |
| Angular_R | 18, −68, 40 | −6.40 | 180 | |
| IPG_R | 18, −68, 40 | −6.40 | 99 | |
| MTG_R | 18, −68, 40 | −6.40 | 66 | |
| SPG_L | 18, −68, 40 | −6.40 | 38 | |
| Female patients with HAT in CSF < Male patients with HAT in CSF | ||||
| PCG_L | −16, −48, 32 | p = 0.001 | −5.52 | 176 |
| Precuneus_L | −16, −48, 32 | p = 0.001 | −5.52 | 125 |
| Calcarine_L | −16, −48, 32 | p = 0.001 | −5.52 | 52 |
| MCG_L | −16, −48, 32 | p = 0.001 | −5.52 | 45 |
CBF, cerebral blood flow; CSF, cerebrospinal fluid. MNI, Montreal Neurological Institute; FWE, Family-wise error; MTP, middle temporal pole; ITG, inferior temporal gyrus; MTG, middle temporal gyrus; MOFG, middle orbitofrontal gyrus; SOFG, superior orbitofrontal gyrus; IOFG, inferior orbitofrontal gyrus; TIFG, triangle inferior frontal gyrus; STP, superior temporal pole; OIFG, operculum inferior frontal gyrus; IOG, inferior occipital gyrus; SOG, superior occipital gyrus; MOG, middle occipital gyrus; STG, superior temporal gyrus; MTG, middle temporal gyrus; RO, rolandic operculum; SPG, superior parietal gyrus; IPG, inferior parietal gyrus; MCG, middle cingulum gyrus (MCG); PCG, post cingulum gyrus; L, left; R, right; HAT, high antibody titers; LAT, low antibody titers.