Table 3.

Negative lifestyle changes in 2001–2004 (prior to diagnosis), 2004–2007 (around diagnosis) and 2007–2010 (following diagnosis)-in women who were and were not diagnosed with OA between 2004 and 2007.

Lifestyle change	Women diagnosed with OA		Women not diagnosed with OA		p-value	OR (95% CI)c	p-value for interaction of OA with time
	N	% who made a negative change	N	% who made a negative change
Weight gain (≥ 5 kg)
Period prior to OA diagnosis (2001–04)	517	20.9	3342	18.0	0.12	1.02 (0.97, 1.07)	0.22
Period around OA diagnosis (2004–07)	538	21.4	3452	14.5	< 0.001	1.08 (1.03, 1.14)
Period following OA diagnosis (2007–10)	564	16.8	3700	16.8	0.96	0.97 (0.92, 1.02)
Total sitting time (increase > 1 h/day)
Period prior to OA diagnosis	523	41.3	3266	36.4	0.03	1.04 (1.00, 1.08)	0.57
Period around OA diagnosis	467	38.3	3209	35.1	0.18	1.02 (0.98, 1.07)
Period following OA diagnosis	542	38.4	3386	32.3	0.005	1.07 (1.03, 1.11)
Decrease in PA (decrease > 150 MET.mins/week)
Period prior to OA diagnosis	518	29.2	3406	30.6	0.50	1.00 (0.96, 1.05)	0.58
Period around OA diagnosis	510	37.5	3347	36.6	0.71	1.02 (0.98, 1.06)
Period following OA diagnosis	522	38.9	3479	39.6	0.76	1.02 (0.98, 1.07)
Started smokinga
Period prior to OA diagnosis	519	10.8	3229	1.3	< 0.001	1.56 (1.43, 1.70)	0.30
Period around OA diagnosis	495	9.3	3247	0.7	< 0.001	1.69 (1.52, 1.88)
Period following OA diagnosis	559	8.9	3490	0.8	< 0.001	1.66 (1.49, 1.84)
Increase in alcoholb
Period prior to OA diagnosis	503	1.6	3293	3.7	0.02	0.82 (0.71, 0.95)	0.33
Period around OA diagnosis	533	2.4	3367	2.1	0.59	1.04 (0.92, 1.17)
Period following OA diagnosis	541	1.5	3551	2.3	0.21	0.93 (0.79, 1.08)

^aIncludes all ex- and non-smokers.

^bIncludes all non-risky alcohol drinkers.

^cOdds ratio adjusted for chronic diseases, depressive symptoms, pain, physical function, menopausal status, OR (95% CI) is the odds in the OA group versus the No-OA group.