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. Author manuscript; available in PMC: 2024 Mar 15.
Published in final edited form as: Cell Rep. 2024 Jan 23;43(2):113700. doi: 10.1016/j.celrep.2024.113700

Figure 5. Cyclooxygenase (COX) activity regulates NLRP3 activity but not NLRC4.

Figure 5.

(A-H) Cellular viability (A and D), IL-1β (B and E), and IL-18 (C) produced by LPS-primed (200 ng/mL for 3 h) WT and Nlrp3−/− BMDMs in response to NLRP3 stimulant nigericin (10 μM, 1 h) or ATP (5 mM, 30 min) in presence of COX inhibitors indometacin (100 μM) or celecoxib (10 μM).

(F-I) Cellular viability (F), IL-1β (G), IL-18 (H), and PGE2 (I) produced by unprimed WT and Nlrp3−/− BMDMs in response to S. Typhimurium infection (MOI 10, 2 h) in presence of COX inhibitors.

*p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 (one-way analysis of variance with Tukey’s multiple comparison test). Data are from three independent experiments (mean and SEM).