Fig. 2.

Rare germline pathogenic variants identified in the 1436 RCC patients. The proportion of ccRCC or nccRCC patients carrying rare (MAF <1%) germline pathogenic variants in one of the 143 germline cancer predisposition genes was tested. Three known CHEK2 low-penetrance variants were treated separately from the rest of the PVs in CHEK2. Numbers next to the bars indicate the counts of RCC patients carrying PVs in each gene. ccRCC = clear cell RCC; MAF = minor allele frequency; nccRCC = non–clear cell RCC; PV = pathogenic variant; RCC = renal cell carcinoma.