Fig. 3.

Meta-analysis of CHEK2 risk in ccRCC and nccRCC in European samples. Tables and forest plots summarize the model estimate summary statistics from the sub-European meta-analysis for CHEK2 germline variants. The area of squares is proportional to the –log10 of the p values, and the horizontal bars indicate 95% confidence intervals for the estimated odds ratio. Test statistics from Fisher’s exact and GLM tests were plotted for comparison. (A) Summary tables for CHEK2 LOF excluding the low-penetrance variants. (B) Summary tables for the CHEK2 founder variant p.Ile157Thr. (C) Summary tables for the CHEK2 founder variant p.Ser428Phe. ccRCC = clear cell RCC; CI = confidence interval; EUR = European; GLM = generalized linear model; LOF = loss of function; Mut = mutations; nccRCC = non–clear cell RCC; OR = odds ratio; pLOF = putative loss of function; RCC = renal cell carcinoma; WT = wild type.