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Examples of rare germline copy number variants (CNVs) in established cancer-predisposing genes. (A) Bar-plot summarizing the counts of deletions and duplications including the germline cancer predisposing genes. (B–D) Denoised linear copy ratio (DCR) plots indicating heterozygous copy number deletion with a copy ratio of 1 for the carriers of CNVs. The blue line indicates DCR for the CNV carrier, and the dotted grey lines indicate DCR for the rest of wild-type samples.
