TABLE 2.
Tumor induction by virus with S257C mutationa
| Characteristic | PTA with S257C mutation | PTA |
|---|---|---|
| No. of mice with tumors/total no. of mice | 48/48 | 256/259 |
| Mean age (days) at necropsy (range) | 83 (53–227) | 108 (43–381) |
| No. of epithelial tumors (%) | ||
| Hair follicle | 40 (83) | 229 (88) |
| Thymus | 33 (69) | 227 (88) |
| Mammary gland | 23 (48) | 126 (49) |
| Salivary gland | 0 (0) | 148 (57) |
| No. of mesenchymal tumors (%) | ||
| Kidney | 17 (35) | 123 (47) |
| Bone | 12 (25) | 58 (22) |
| Subcutaneous connective tissue | 2 (4) | 56 (22) |