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In vivo therapeutic effects of DNRS gel. a) Experimental timeline of gel treatment. b) Clinical score and c) body weight of CIA rats for different groups. d) Thermographic images and e) temperature of inflammatory joints after various treatments on different days. f) H&E staining of synovium. g) H&E and Masson staining of ankle joints. Scale bars: 100 μm. n = 6, n.s. represents not significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
