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. 2024 Mar 8;36:287–300. doi: 10.1016/j.bioactmat.2024.03.002

Scheme 1.

Scheme 1

Schematic illustration of the fabrication of self-healing injectable hydrogel and the mechanism of bone protection by regulating the microenvironment of RA. DNRS gel depletes excessive NO and releases H2S in the presence of cysteine, and sustained release MTX.