Table 2.

Bone formation markers.

Bone formation markers	Tissue origin	Sample	Significance
Alkaline phosphatase (ALP)	Bone, Liver	Serum	Reliable bone marker in subjected to normal liver function
Bone alkaline phosphatase (BALP)	Bone	Serum	Sensitive and reliable marker of bone metabolic activity
Procollagen type 1 N-terminal propeptide (P1NP)	Bone, Skin	Serum	Sensitive biomarker of bone formation (Specific osteoblast and fibroblast derivative)
Procollagen type 1 C-terminal propeptide (P1CP)	Bone, skin, soft tissue	Serum	Indicator of COL1A1 synthesis in bone matrix formation
Osteocalcin	Bone, Thrombocytes	Serum	Late marker of bone formation