Figure 1.

Adult human subventricular zone cell atlas

(A) Schematic diagram illustrating the sources and brain regions of adult human SVZ neurosurgical samples. Samples were derived from patients with ages ranging from 38 to 72 years old. Eight samples were derived from females and 7 from males. The marks on the right panels show the 15 subventricular zone sample sites.

(B) t-distributed stochastic neighbor embedding visualization (tSNE) of adult SVZ cells colored by cell types. NSC—neural stem cell, NK—natural killer, RBC—red blood cell.

(C) Heatmap of top 100 genes expressed in each SVZ cell type.

(D) Localization of cell types within normotypic autopsy SVZs using cell-type-specific protein markers. Scale bar, 100mm.

(E) Expression of indicated genes in all SVZ cell type clusters visualized on tSNE.