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. 2024 Mar 1;5:1359202. doi: 10.3389/fragi.2024.1359202

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Copyright © 2024 Holmes, Duan, Bagley, Wu, Loika, Kulminski, Yashin, Arbeev and Ukraintseva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HRS females: (A) mean trajectories of body weight in APOE4 carriers vs. non-carriers. (B) Survival trajectories by different ages at reaching maximum values of weight. (C) Survival trajectories by different weight slopes. HRS males: (D) mean trajectories of body weight in APOE4 carriers vs. non-carriers. (E) Survival trajectories by different age categories at reaching maximum values of weight. (F) Survival trajectories by different weight slopes. Cox proportional hazards p-value (CoxPH P) is provided as a measure of the statistical significance of differences between survival curves in the respective groups.