TABLE 3.
Profile of neutralizing activities of Fabs 201 and 202 against various SIV isolatesa
| Prepn | Concn (μg/ml) of Fab or IgG needed to neutralize indicated SIV strain
|
||||
|---|---|---|---|---|---|
| Homologous strains
|
Heterologous strains
|
||||
| smH4 | smB670 | smE660 | SIVmac251 | SIVmac239 | |
| Fab 201 | 0.078 | <0.042 | ND | >5.53 | >5.53 |
| Fab 202 | 0.117 | 0.038 | ND | >2.00 | >2.00 |
| SIVIG | ND | 1.35 | 0.78 | 40.4 | >50.0 |
a
The concentrations of Fab or SIVIG that resulted in 50% protection of CEM×174 cells from virus-induced cell killing are shown. ND, not determined.