Table 2.

Effect of coprescription of a BZD on outcomes in people receiving opioid replacement therapy

Outcome	HR*	P value	95% CI
All-cause mortality	1.17	<0.001	1.10 to 1.24
Drug-related death	1.14	0.003	1.04 to 1.24
Not drug-related death	1.19	<0.001	1.09 to 1.30

*Adjusted for age at first ORT prescription dispensed, age at first dispense squared and age at first dispense cubed, sex, Scottish Index of Multiple Deprivation, Scottish urban-rural classification, ever prescription of z-drugs and ever prescription of opioid analgesics.

BZD, benzodiazepine; ORT, opioid replacement therapy.