Table 2.
Protein biomarkers that differ by percentage of interstitial features at baseline in COPDGene
| Biomarker | Mean in those with less interstitial features | Mean in those with more interstitial features | FDR p value |
| Angiopoietin 2 | 5.2 | 5.28 | 7.25×10−5 |
| Apolipoprotein A-I | 9.81 | 9.76 | 1.41×10−4 |
| Matrix Metalloproteinase 7 | 7.76 | 7.88 | 2.08×10−4 |
| Follicle stimulating hormone | 7.43 | 7.77 | 6.69×10−5 |
| Macrophage inflammatory protein 1 alpha | 6.69 | 6.8 | 2.46*10−5 |
| Pulmonary and activation regulated chemokine | 8.8 | 8.93 | 2.46×10−5 |
| Pleiotrophin | 7.36 | 7.43 | 2.49×10−4 |
| Cathepsin B | 7.35 | 7.44 | 2.46×10−5 |
| Retinoic acid receptor responder protein 2 | 7.97 | 8.03 | 5.03×10−5 |
| Coiled-coil domain-containing protein 80 | 7.65 | 7.72 | 1.53×10−4 |
| Cystatin-M | 8.77 | 8.68 | 2.56×10−4 |
| Carbonic anhydrase 6 | 8.47 | 8.32 | 4.40×10−4 |
| Growth/differentiation factor 15 | 7.23 | 7.35 | 3.10×10−5 |
| Macrophage metalloelastase | 7.24 | 7.4 | 2.46×10−5 |
| Prothrombin | 11.92 | 11.88 | 2.40×10−4 |
| Fatty-acid-binding protein | 9.75 | 9.88 | 1.53×10−4 |
| Prostate-specific antigen | 6.88 | 6.66 | 1.53×10−4 |
| Fibulin 3 | 7.46 | 7.51 | 5.35×10−4 |
| Leptin | 8.81 | 9.18 | 2.13×10−9 |
| Galectin 9 | 7.13 | 7.23 | 2.02×10−4 |
FDR, false discovery rate.