Table 4.
Multivariable MR results for adjusting the effect of serum urate on the risk of COPD
| Exposure | SNP (n) | β | SE | OR (95% CI) | P value |
| Serum urate | 16 | 0.13 | 0.06 | 1.137 (1.014 to 1.274) | 0.027 |
| eGFR (creatinine) | 182 | 0.23 | 0.54 | 1.258 (0.434 to 3.647) | 0.672 |
| Alcohol consumption | 3 | 0.11 | 0.32 | 1.119 (0.592 to 2.114) | 0.729 |
| PM2.5 | 3 | 0.70 | 0.51 | 2.016 (0.745 to 5.456) | 0.168 |
| Pack years of smoking | 5 | 1.73 | 0.20 | 5.643 (3.845 to 8.282) | <0.001 |
COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; MR, Mendelian randomisation; PM2.5, particulate matter air pollution; SNP, single nucleotide polymorphism.