Table 2.

Adjusted association of covariates with recurrence-free survival estimated using a multivariable Cox model

Factor	Comparison	HR (95% CI)	Nominal p value
Treatment arm	Placebo	Reference	0.0001
	Pembrolizumab	0.56 (0.43 to 0.75)
Melanoma subtypes	Nodular melanoma	Reference	0.631
	Non-nodular melanoma	0.94 (0.71 to 1.23)
Tumor thickness	≤4 mm	Reference	0.0246
	>4 mm	1.43 (1.05 to 1.95)
Ulceration	No	Reference	0.131
	Yes	1.32 (0.92 to 1.90)
Mitotic rate	<5 per mm2	Reference	0.0004
	≥5 per mm2	1.65 (1.25 to 2.18)
Tumor-infiltrating lymphocytes	Present	Reference
	Absent	1.06 (0.74 to 1.50)	0.762
	Unknown	1.09 (0.80 to 1.50)	0.584

p values in bold are nominally significant (p<0.025).