Table 3.

Adjusted association of covariates with distant metastasis-free survival estimated using a multivariable Cox model

Factor	Comparison	HR (95% CI)	Nominal p value
Treatment arm	Placebo	Reference	0.0019
	Pembrolizumab	0.58 (0.41 to 0.82)
Melanoma subtypes	Nodular melanoma	Reference	0.822
	Non-nodular melanoma	1.04 (0.74 to 1.45)
Tumor thickness	≤4 mm	Reference	0.0946
	>4 mm	1.38 (0.95 to 2.01)
Ulceration	No	Reference	0.0769
	Yes	1.51 (0.96 to 2.39)
Mitotic rate	<5 per mm2	Reference	0.0034
	≥5 per mm2	1.67 (1.19 to 2.36)
Tumor-infiltrating lymphocytes	Present	Reference
	Absent	1.35 (0.89 to 2.06)	0.160
	Unknown	1.34 (0.90 to 1.97)	0.147

p values in bold are nominally significant (p<0.025).