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. 2024 Feb 15;7(3):771–786. doi: 10.1021/acsptsci.3c00308

Table 2. EC50 Values and Hill Coefficients (nH) of ACh in the Presence of the Indicated Concentrations of BPCs at Human α7 and (α1)2β1εδ nAChRs.

compound α7
(α1)2β1εδ
  EC50 95% CI μMa nH EC50 95% CI μMa nH
ACh 36.5 33.5–40.0 1.90 15.4 13.1–18.8 1.22
+3 μM MB327 43.8 33.6–58.2 1.66      
+10 μM MB327       13.0 8.1–26.1 1.10
+3 μM PTM0002 51.6 42.5–63.2 1.57      
+10 μM PTM0007 35.8 29.2–45.7 1.93      
+3 μM PTM0015 49.2 31.7–82.2 1.53      
+0.3 μM PTM0022 58.8 44.0–81.4 1.46      
+1 μM PTM0022       10.3 7.3–17.2 1.06
a

Values represent 95% confidence intervals. The corresponding dose–response curves are shown in Figure 1C.