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. 2024 Feb 15;7(3):771–786. doi: 10.1021/acsptsci.3c00308

Table 3. IC50 Values and Hill Coefficients (nH) for MB327 and PTM0022 at Human α7 and α7M253L nAChRs.

  α7
α7 M253L
 
compound IC50 95% CI μMa nH IC50 95% CI μMa nH IC50(α7)/IC50(M253L)
MB327 3.50 2.73–4.51 –0.84 0.84 0.69–1.03 –0.98 4.17
PTM0022 0.20 0.17–0.23 –1.07 0.30 0.25–0.35 –1.76 0.67
a

Values represent 95% confidence intervals. Corresponding dose–inhibition curves are shown in Figure 2B.