Table 2.

IL-10 polymorphisms and their association with cancer development and risk

Type of cancer	IL-10 polymorphism	Variant	Contribution	References
Chronic lymphocytic leukaemia (CLL)	−1082	1082 G/A and A/A	Increased risk to CLL	(Ref. 220)
Prostate cancer	−1082	−1082 AA	High risk factor and susceptibility	(Ref. 221)
Cervical cancer	rs1800896	AG/AA genotypes	High risk factor and susceptibility	(Ref. 222)
Breast cancer	rs1800896 rs1800871 rs1800872	AA genotypes	High risk factor and susceptibility	(Ref. 223)
Gastric carcinoma	−1082, −592 −819	GCC, ATA, AG haplotype	Advanced stage, high risk factor and susceptibility,	(Ref. 224)
Oral cancer	−1082	−1082 G allele	High susceptibility to oral carcinoma	(Ref. 225)
Multiple myeloma	IL-10G IL-10R	IL-10 G 136/136, IL-10R 112/114	Increased susceptibility	(Ref. 226)
Lung cancer	−592	A > C	Increased risk	(Ref. 227)
Non-Hodgkin's lymphoma	−1082 −592 −819	−1082 AA, ATA, ACC haplotypes	More aggressive form of the disease.	(Ref. 228)
Acute lymphoblastic leukaemia	−1082	−1082 GG	Low possibility of poor response to prednisolone	(Ref. 229)
Acute myeloid leukaemia	−819	−819 T/C	Increased risk of AML	(Ref. 230)
Colorectal cancer	−819	T > C genotypes	Increased risk of colorectal cancer	(Ref. 231)
Cutaneous malignant melanoma	−1082 −592 −819	High risk, larger tumour thickness, disease progression and shorter survival	1082 AA, 1082 GG, ACC/ACC, ACC/ATA, ATA/ATA	(Refs 232, 233)