TABLE 1.
Variability of p6 promoter sequences from patients with different B19 virus-associated diseasesa
| Isolate | Disease and/or symptoms of patient | No. of mutations in p6 sequence/total no. of bases (%) |
|---|---|---|
| K | Acute infection, asymptomatic | 3/389 (0.77) |
| KS | Acute infection, asymptomatic | 3/388 (0.77) |
| 2/II | Acute infection | 0/388 (0) |
| A | Persistent infection | 1/389 (0.26) |
| B | Persistent infection | 0/389 (0) |
| 5 | Anemia after transplantation | 1/389 (0.26) |
| S471 | Arthritis | 0/389 (0) |
| V6 | Arthritis | 1/388 (0.26) |
| S758 | Arthritis | 2/388 (0.52) |
| SP | Arthritis | 2/388 (0.52) |
| S724 | Arthritis | 3/387 (0.78) |
a
Sera from patients with B19 virus infection were used for determination of the sequence of the p6 promoter to examine whether there was a correlation with the respective clinical manifestations and variability in the p6 promoter sequence. The sequences were compared to those published by Deiss et al. (7) and Shade et al. (27).