Table 4.
Description of assessments
| Category | Type | Assessment | Time of data collection (week) | Location of data collection | Data storage during data collection |
|---|---|---|---|---|---|
| Home assessments (cognitive tests) | Verbal learning and memory | California Verbal Learning Test [37] | 1, 12 | Home | Amazon’s cloud storage system |
| Working memory | N-back task [38] | ||||
| Episodic memory | Face-name associative memory task [39] | ||||
| Episodic memory | Pattern separation task [40] | ||||
| Executive function | Task-switching task [41, 42] | ||||
| Executive function | Flanker task [43] | ||||
| Visuospatial function | Spatial orientation task [44] | ||||
| Verbal fluency | Thurstone Word Fluency Test [45] | ||||
| Home assessments (emotion questionnaires) | Emotional memory | Emotional memory task [46] | |||
| Emotional memory | Mood prediction and memory | ||||
| Theory of mind | Reading the mind in the eyes test [47] | ||||
| Mood | Positive and Negative Affect Schedule (PANAS) [48] | ||||
| Stress | Daily Inventory of Stress Events [49] | ||||
| Depression/anxiety/stress | Depression Anxiety Stress Scales-Short Form (DASS-21) [50] | ||||
| Mindfulness | Five Facet Mindfulness Questionnaire (FFMQ) [51, 52] | ||||
| Home assessments (other questionnaires) | Sleep | Epworth Sleepiness Scale [53] | |||
| Sleep | Karolinska Sleepiness Scale [54] | ||||
| Demographics | Demographic information | 1 | |||
| Physical activity | Physical activity ratings [55] | ||||
| Survey | Post study survey | 12 | |||
| Blood sample | N/A | Plasma amyloid beta levels | 2, 7, 12 | Lab | Lab freezer |
| Plasma pTau | |||||
| Plasma total tau | |||||
| Urine sample | N/A | Amyloid beta levels | |||
| MRI session | Structural MRI | T1-weighted sequence | 2, 7, 12 | Imaging center | Flywheel |
| T2-weighted sequence | |||||
| LC low resolution (proton density-weighted sequence) | |||||
| LC high resolution (proton density-weighted sequence) | |||||
| Hippocampal high resolution (T2-weighted sequence) | |||||
| Fluid-attenuated inversion recovery (FLAIR) | 12 | ||||
| Pulse | Pulse oximeter recording photoplethysmogram (PPG) signal from finger | 2, 7, 12 | Lab laptop and external hard drive | ||
| EEG | N/A | Oddball task (passive and active) [56, 57] | 2, 12 | Lab | Lab computer and flywheel |
| Resting state EEG measure (with eyes open and closed) | |||||
| Training mimicking EEG recording | 12 | ||||
| Neuropsychological tests | Cognition | Trials A & B [58] | 2, 12 | Amazon’s cloud storage system | |
| Animal fluency [59] | |||||
| Multilingual naming test [60] | 2 | ||||
| Montreal Cognitive Assessment (MoCA) [61] | |||||
| Functional Activities Questionnaire [62] | |||||
| Surveys | N/A | Profile of Mood States (POMS) [63] | 2, 7, 12 | Lab computer and flywheel | |
| Daily Inventory of Stressful Events (DISE) [49] | |||||
| Sleep survey | |||||
| Baseline pulse measures | Pulse during rest and during 4-s paced breathing | Pulse oximeter recording photoplethysmogram (PPG) signal from earlobe | 2 | Lab after MRI | Amazon’s cloud storage system |
| Pulse during rest | Home | ||||
| Breathing training | Pulse during paced breathing | 3–11 | |||
| Cognitive training | Brain games | Brain game performance | 2–11 |