Table 3.
Sex-stratified results of HNSCC PRS with significant associations in the UK Biobank
| Phenotype description | Male (n = 140,232) | Female (n = 168,260) | Sex-interaction | |||
|---|---|---|---|---|---|---|
| No. of cases (%) | OR per SD increase (95% CI) | P-value | OR per SD increase (95% CI) | P-value | P-value for interaction | |
| HNSCC PRS | ||||||
| Tobacco use disorder | 20,599 (6.7%) | 1.06 (1.04–1.08) | 3.06 × 10−8 | 1.07 (1.04–1.09) | 1.26 × 10−8 | .207 |
| Alcoholism | 9636 (3.1%) | 1.06 (1.03–1.09) | 1.44 × 10−5 | 1.07 (1.03–1.11) | 9.08 × 10−5 | .886 |
| Alcohol-related disorders | 6015 (1.9%) | 1.08 (1.05–1.12) | 5.95 × 10−7 | 1.07 (1.02–1.13) | 4.35 × 10−3 | .830 |
| Emphysema | 2096 (0.7%) | 1.10 (1.04–1.16) | 1.50 × 10−3 | 1.13 (1.05–1.21) | 9.79 × 10−4 | .470 |
| Chronic airway obstruction | 9151 (3.0%) | 1.04 (1.02–1.08) | 2.95 × 10−3 | 1.05 (1.02–1.09) | 2.94 × 10−3 | .591 |
| Cancer of bronchus; lung | 2781 (0.9%) | 1.10 (1.05–1.16) | 2.74 × 10−4 | 1.06 (1.00–1.12) | 4.04 × 10−2 | .365 |
Analyses were adjusted by age, genotype array, and PC 1 to 10
Abbreviations: HNSCC head and neck squamous cell carcinoma, OC oral cavity cancer, OPC oropharynx cancer, PRS polygenic risk score, SD standard deviation, OR odds ratio, CI confidence interval, PC principal component