Table 4.
Subgroup-stratified results of HNSCC PRS with significant associations in the UK Biobank
| Phenotype description | Younger (age ≤ 60 years) | Elderly (age > 60 years) | Never-smoker | Ever-smoker | ||||
|---|---|---|---|---|---|---|---|---|
| (n = 166,624) | (n = 141,868) | (n = 119,038) | (n = 190,562) | |||||
| OR per SD increase (95% CI) | P-value | OR per SD increase (95% CI) | P-value | OR per SD increase (95% CI) | P-value | OR per SD increase (95% CI) | P-value | |
| HNSCC PRS | ||||||||
| Tobacco use disorder | 1.08 (1.06–1.10) | 1.54 × 10−13 | 1.04 (1.02–1.06) | 3.77 × 10−4 | 1.02 (0.94–1.10) | .631 | 1.06 (1.04–1.07) | 3.11 × 10−12 |
| Alcoholism | 1.07 (1.04–1.10) | 1.16 × 10−5 | 1.06 (1.03–1.09) | 1.38 × 10−4 | 1.05 (1.00–1.09) | 3.09 × 10−2 | 1.07 (1.04–1.10) | 8.80 × 10−8 |
| Alcohol-related disorders | 1.09 (1.05–1.13) | 6.24 × 10−7 | 1.07 (1.02–1.11) | 3.44 × 10−3 | 1.04 (0.98–1.11) | .149 | 1.08 (1.05–1.12) | 8.20 × 10−8 |
| Emphysema | 1.13 (1.04–1.22) | 3.22 × 10−3 | 1.10 (1.04–1.16) | 4.34 × 10−4 | 1.26 (1.07–1.48) | 4.97 × 10−3 | 1.09 (1.04–1.14) | 3.70 × 10−4 |
| Chronic airway obstruction | 1.06 (1.02–1.10) | 6.13 × 10−3 | 1.04 (1.02–1.07) | 1.25 × 10−3 | 0.99 (0.93–1.06) | .864 | 1.05 (1.02–1.07) | 6.61 × 10−5 |
| Cancer of bronchus; lung | 1.06 (0.99–1.14) | 7.86 × 10−2 | 1.09 (1.04–1.14) | 1.90 × 10−4 | 1.05 (1.01–1.09) | .355 | 1.08 (1.04–1.13) | 1.25 × 10−4 |
All analyses were adjusted by age, sex, genotype array, and PC 1 to 10
Abbreviations: HNSCC head and neck squamous cell carcinoma, PRS polygenic risk score, SD standard deviation, OR odds ratio, CI confidence interval, PC principal component