Figure 1.

FXR agonists promote expression of GLP‐1R in β cells. A, B, GLP‐1R mRNA (A) and protein (B) were determined in INS‐1 832/13 cells by treatment with DMSO or 5 μmol/L GW4064 for 2 h (A) and 48 h (B), respectively. Bars represent means ± SEM, n = 3 (A) or 4 (B). *P < 0.05; **, P < 0.01. C, D, GLP‐1R mRNA (C) and protein (D) were determined in vector control and FXR overexpressing INS‐1 832/13 cells. Bars represent means ± SEM, n = 3. *P < 0.05. E, F, GLP‐1R mRNA (E) and protein (F) were examined in islets isolated from SD rats. The rats were subjected to intraperitoneal injection of CDCA at a dose of 20 mg/kg for 2 wks. Bars represent means ± SEM, n = 3 rats per group. *P < 0.05; **P < 0.01