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Simulated and observed variability in PQ plasma concentrations in women at postpartum. Simulated (symbols and black lines) and observed (red lines) variability in plasma exposure of PQ after 0.5 mg/kg daily dosing of PQ in nursing mothers. Median and range are shown for AUC (a) and C max (b) for each virtual trial and the observed data. AUC, area under the curve; C max, maximum plasma concentration; PQ, primaquine.
