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Simulated and observed PQ plasma concentration profiles in breastfeeding infants. Simulated mean concentration time profiles of PQ following multiple oral daily doses of 2.98 μg/kg (a) and 9.07 μg/kg (b) in children aged greater than or equal to 28 days old. The gray lines represent the 5th and 95th percentiles of the total virtual population. It was assumed that the total daily dose was split across six doses given every 4 h. PQ, primaquine.
