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. 2024 Mar 15;23:33. doi: 10.1186/s12938-024-01226-y

Table 2.

LOC for disease modeling and drug screening

Picture Cell type Description References
graphic file with name 12938_2024_1226_Figf_HTML.gif Huh-7 It combines COC with PDMS and can be used for screening and cell analysis of lipid intermediates. It is also suitable for rapid prototyping and cultivate functional liver cancer Huh-7 cell lines [7]
graphic file with name 12938_2024_1226_Figg_HTML.gif hiPSCs This chip combines stem cell organoids with organ chip technology and is established using a hiPSC-derived liver organoid chip system [29]
graphic file with name 12938_2024_1226_Figh_HTML.gif

HepaRGa

LX2 cellsb

 For the detection of NAFLD. The changes of lipid partition in hepatic lobules with the progress of NAFLD were proved at chip level [30]
graphic file with name 12938_2024_1226_Figi_HTML.gif iHep, iEndo It was prepared using the innovative equipment MINERVA 2.0. Evaluation of the drug donepezil for Alzheimer 's disease and screening for hepatotoxicity [31]
graphic file with name 12938_2024_1226_Figj_HTML.gif HepG2 It is used to study the anti-cancer effects of statins and their metabolites [32]

aHepaRG: hepatoma cells

bLX2 cells: Human hepatic stellate cells. The figures in this table were created with BioRender.com (agreement number: OK26HQ3492)