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PBPK model output from a simulation of 1000 term neonates aged 0–7 days receiving fosfomycin 100 mg/kg i.v. bolus q12h (a) and amikacin 15 mg/kg i.v. bolus q24h (b), with simulation data sampled every 5 min. The variable C max values are due, in part, to the simulated ontogeny and growth of each individual neonate over the simulation time period. C max, maximum plasma concentration; PBPK, physiologically‐based pharmacokinetic.
