FIGURE 5.

Probability of target attainment for amikacin monotherapy for amikacin 15 mg/kg IV q24h in neonates of PNA 0–7 days and 7–28 days. Panels (a and c) represent the target attainment for 1−log₁₀ CFU/mL reduction (AUC:MIC >62.5). Panels (b and d) represent the target attainment for bacterial stasis (AUC:MIC >21.4). Panels (a and b) are determined in term neonates. Panels (c and d) are determined in neonates born at 30 weeks gestation. AUC, area under the curve; MIC, minimum inhibitory concentration; PNA, post‐natal age; PTA, probability of target attainment.