Table 3.
MIC50, MIC90, range and percent of P. multocida and M. haemolytica isolates collected from high-risk beef stocker calves prior to and 14 d after administration of saline susceptible to 12 antimicrobials at the time of arrival processing
| Pasteurella multocida | Mannheimia haemolytica | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Antimicrobial | Sampling occasion | MIC50 (μg/mL) | MIC90 (μg/mL) | Range (μg/mL) | % Susceptible | MIC50 (μg/mL) | MIC90 (μg/mL) | Range (μg/mL) | % Susceptible |
| Ampicillin | 1 | ≤0.25 | ≤0.25 | ≤0.25 | N/A | N/A | N/A | N/A | N/A |
| 2 | ≤0.25 | ≤0.25 | ≤0.25 | N/A | ≤0.25 | 0.5 | ≤0.25 to 0.5 | N/A | |
| Ceftiofur | 1 | ≤0.25 | ≤0.25 | ≤0.25 | 100 | N/A | N/A | N/A | N/A |
| 2 | ≤0.25 | ≤0.25 | ≤0.25 | 100 | ≤0.25 | 2 | ≤0.25 to 2 | 100 | |
| Chlortetracycline | 1 | ≤0.5 | 2 | ≤0.5 to 2 | N/A | N/A | N/A | N/A | N/A |
| 2 | ≤0.5 | 2 | ≤0.5 to 8 | N/A | >8 | >8 | 0.5 to >8 | N/A | |
| Danofloxacin | 1 | ≤0.125 | ≤0.125 | ≤0.125 | 100 | N/A | N/A | N/A | N/A |
| 2 | ≤0.125 | ≤0.125 | ≤0.125 | 100 | ≤0.125 | >1 | ≤0.125 to >1 | 86 | |
| Enrofloxacin | 1 | ≤0.125 | ≤0.125 | ≤0.125 | 100 | N/A | N/A | N/A | N/A |
| 2 | ≤0.125 | ≤0.125 | ≤0.125 | 100 | ≤0.125 | >2 | ≤0.125 to >2 | 86 | |
| Florfenicol | 1 | 0.5 | 1 | 0.25 to 1 | 100 | N/A | N/A | N/A | N/A |
| 2 | 0.5 | 1 | 0.25 to 1 | 100 | 1 | >8 | ≤0.25 to >8 | 86 | |
| Oxytetracycline | 1 | ≤0.5 | 4 | ≤0.5 to 8 | 93 | N/A | N/A | N/A | N/A |
| 2 | ≤0.5 | 8 | ≤0.5 to >8 | 80 | >8 | >8 | 0.5 to >8 | 46 | |
| Penicillin | 1 | ≤ 0.125 | 0.25 | ≤ 0.125 to 0.25 | 100 | N/A | N/A | N/A | N/A |
| 2 | ≤ 0.125 | 0.25 | ≤ 0.125 to 0.25 | 100 | 0.5 | 1 | ≤0.125 to 1 | 50 | |
| Spectinomycin | 1 | 16 | 32 | 8 to >64 | 93 | N/A | N/A | N/A | N/A |
| 2 | 16 | >64 | 8 to >64 | 83 | 32 | >64 | ≤8 to >64 | 86 | |
| Tilmicosin | 1 | ≤4 | 32 | ≤4 to >64 | 93 | N/A | N/A | N/A | N/A |
| 2 | ≤4 | 64 | ≤4 to >64 | 86 | 8 | >64 | 8 to >64 | 79 | |
| Tulathromycin | 1 | ≤1 | 32 | 1 to >64 | 93 | N/A | N/A | N/A | N/A |
| 2 | ≤1 | >64 | 1 to >64 | 86 | 8 | >64 | ≤1 to >64 | 86 | |
| Tylosin | 1 | 16 | >32 | 8 to >32 | N/A | N/A | N/A | N/A | N/A |
| 2 | 16 | >32 | 16 to >32 | N/A | >32 | >32 | 8 to >32 | N/A | |
N/A—breakpoints not available or too few isolates to summarize.