Table 3.
Correlation of PRM volumes, anomaly score, and cluster groups with PFTs and clinical data.
| Method | Pulmonary function tests and clinical data | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| FEV1 | FEV1/FVC | TLC | FRC | FRC/TLC | BODE | SGRQ | 6MWT | Duration smoking | ||
|
PRM | |||||||||
| Healthy (%) | 0.71**** (0.68, 0.74) | 0.80**** (0.77, 0.82) | −0.30**** (−0.35, −0.24) | −0.72**** (−0.75, −0.69) | −0.73**** (−0.76, −0.70) | −0.64**** (−0.68, −0.60) | −0.46**** (−0.51, −0.41) | 0.42**** (0.37, 0.47) | −0.27**** (−0.30, −0.20) | |
| PRMfSAD % | −0.61**** (−0.66, −0.57) | −0.68**** (−0.72, −0.64) | 0.24**** (0.18, 0.30) | 0.70**** (0.67, 0.73) | 0.78**** (0.76, 0.81) | 0.53**** (0.48, 0.57) | 0.39**** (0.34, 0.44) | −0.34**** (−0.39, −0.30) | 0.28**** (0.20, 0.31) | |
| PRMEmph % | −0.66**** (−0.69, −0.63) | −0.75**** (−0.77, −0.72) | 0.30**** (0.24, 0.36) | 0.56**** (0.51, 0.61) | 0.44**** (0.39, 0.50) | 0.64**** (0.60, 0.68) | 0.43**** (0.38, 0.48) | −0.42**** (−0.47, −0.37) | 0.18**** (0.11, 0.21) | |
| Anomaly detection (cOOpD) | ||||||||||
| Anomaly score | −0.65**** (−0.69, −0.60) | −0.68**** (−0.72, −0.64) | 0.16**** (0.09, 0.22) | 0.55**** (0.51, 0.60) | 0.56**** (0.51, 0.62) | 0.57**** (0.52, 0.62) | 0.46**** (0.41, 0.51) | −0.41**** (−0.47, −0.35) | 0.27**** (0.19, 0.30) | |
| Clusters | ||||||||||
| 1 | 0.22**** (0.17, 0.29) | 0.27**** (0.21, 0.34) | −0.22**** (−0.28, −0.15) | −0.34**** (−0.41, −0.27) | −0.35**** (−0.43, −0.27) | −0.23**** (−0.29, −0.16) | −0.15**** (−0.21, −0.09) | 0.16**** (0.10, 0.22) | −0.10*** (−0.15, −0.03) | |
| 2 | 0.33**** (0.28, 0.38) | 0.34**** (0.28, 0.39) | −0.06* (−0.12, −0.01) | −0.22**** (−0.28, −0.16) | −0.17**** (−0.25, −0.09) | −0.25**** (−0.30, −0.19) | −0.21**** (−0.26, −0.15) | 0.20**** (0.14, 0.26) | −0.16**** (−0.19, −0.07) | |
| 3 | −0.41**** (−0.46, −0.36) | −0.42**** (−0.47, −0.37) | 0.11*** (0.05, 0.17) | 0.32**** (0.27, 0.38) | 0.29**** (0.22, 0.36) | 0.32**** (0.27, 0.38) | 0.27**** (0.22, 0.32) | −0.24**** (−0.30, −0.19) | 0.18**** (0.10, 0.21) | |
| 4 | 0.04 (−0.01, 0.10) | 0.04 (−0.02, 0.09) | −0.01 (−0.06, 0.04) | −0.06 (−0.10, −0.02) | −0.08* (−0.11, −0.05) | −0.04 (−0.10, 0.02) | −0.04 (−0.10, 0.01) | 0.00 (−0.05, 0.06) | 0.00 (−0.07, 0.04) | |
Confidence intervals are denoted in brackets, per each Pearson correlation coefficient. Correlations are colored according to Cohen’s effect size (26) and only the significant ones are colored. None or very weak effect size is defined by |r| < 0.3, weak 0.3 < |r| <0.5, moderate 0.5 < |r| < 0.7 and large by |r| > 0.7. PRM, parametric response mapping; fSAD, functional Small Airway Disease; Emph, Emphysema; FEV1, Forced Expiratory Volume in 1 s, FEV1/FVC, FEV/Forced Vital Capacity; FRC, Functional Residual Capacity; TLC, Total Lung Capacity; BODE, Body mass index, air-flow Obstruction, Dyspnea, Exercise capacity; SGRQ, St George’s Respiratory Questionnaire; 6MWT, 6 min walking test. **** p < 0.0001, *** p < 0.001, ** p < 0.01, *p < 0.05.