Table 1:

Model physical and computational parameters

Parameter	Symbol	Value
Physical parameters
Cell radius	${𝓡}_c$	$5\hspace{0.33em}\mu m$
Average cell division age	${𝓟}^{mat}$	18 min
Number of neighbors for overcrowding	${𝓝}^{max}$	5 cells
Cell neighborhood radius	${𝓡}_N$	$15\hspace{0.33em}\mu m$
Cell-cell repulsive spring stiffness	$k_c$	$50\hspace{0.17em}\mu g/\mu m\cdot s^2$
Vessel radius	${𝓡}_v$	$10\hspace{0.17em}\mu m$
Cell-vessel repulsive spring stiffness	$k_v$	$100\hspace{0.17em}\mu g/\mu m\cdot s^2$
Medium viscosity	$v$	$250\hspace{0.17em}\mu g/\mu m\cdot s$
Time of drug injection	${𝓝}_{in\hspace{0.17em}j}$	250 min
Drug influx from the vessel	${𝓙}_{\gamma }$	$5\hspace{0.17em}\sigma g/\mu m^3\cdot s$
Drug diffusion coefficient	${𝓓}_{\gamma }$	$10\hspace{0.17em}\mu m^2/s$
Drug uptake rate	${𝓤}_{\gamma }$	$0.015\hspace{0.33em}{s}^{-1}$
Cell sensing radius	${𝓡}_{\gamma }$	$3\hspace{0.17em}\mu m$
Drug level for cell killing	${𝓠}^{thr}$	$4\hspace{0.17em}\sigma g/\mu m^3$
Probability parameters
Probability of mutation	${𝓟}^{mut}$	0.05 or 0.005
Probability of random death	${𝓟}^{die}$	0.8
Probability of drug induced death	${𝓟}_{𝓠}^{die}$	0.85
Computational Parameters
Domain size	$\Omega$	${\left[\text{-}100,100\right]}^2\hspace{0.17em}\mu m$
Grid width	$h_g$	$5\hspace{0.17em}\mu m$
Time step	$\Delta t$	$0.25\hspace{0.17em}s$
Number of iterations	$N^{total}$	100,000
Scaling parameter	$\sigma$	10−19