Fig. 2. PtdChos can deplete the most abundant plasma proteins in protein corona.
a, Comparative analysis of protein abundance and rankings in untreated plasma versus protein corona profiles, both with and without the addition of small molecules (note that albumin ranked 1st in all samples). b, A stream (or alluvial) diagram illustrating the significant depletion of abundant plasma proteins, particularly albumin, following the incubation of plasma with NPs and PtdChos (only shared proteins with plasma are included). c, The total count of proteins identified in plasma samples incubated with NPs, comparing treatments with and without PtdChos at various concentrations (mean ± SD of three technical replicates). d, A stream diagram demonstrating the depletion pattern of abundant plasma proteins, especially albumin, in response to NP addition and enhanced with escalating concentrations of PtdChos (only shared proteins with plasma are included).