Fig. 1. Small molecules affect the plasma proteome sampling.

a, The number of quantified proteins in plasma, untreated protein corona and protein coronas in the presence of small molecules and molecular sauces (mean ± SD of three technical replicates). The cumulative number of unique proteins identified using untreated protein corona and corona treated with various small molecules is also shown using the purple bar. For fair comparison, the database was performed individually for each small molecule. b, The distribution of averaged normalized abundances of three technical replicates for proteins quantified in the plasma, untreated protein corona and protein coronas in the presence of small molecules and molecular sauces (center line, median; box limits contain 50%; upper and lower quartiles, 75 and 25%; maximum, greatest value excluding outliers; minimum, least value excluding outliers; outliers, more than 1.5 times of upper and lower quartiles). c, Clustered heatmap of normalized abundance of all 1793 proteins quantified across all samples. White denotes not detected. d, Clustered heatmap of normalized abundance of 117 shared proteins across all samples. Experiments were performed in three technical replicates.