Figure 3.

Mutational profiling in personalized therapy. Presentation of a patient with melanoma at different tumor stages. Included are recommended screening and therapeutic managements, which vary depending on tumor progression. NGS has become an important part of advanced melanoma care. MSP, melanoma-specific mutation panel; NGS, next-generation sequencing; TR, tumor resection; PARE, personalized analysis with rearranged ends; TIL, tumor infiltrating lymphocyte. Reproduced with permission from Ref. [103]. Copyright 2012, Elsevier.