Figure 2. Example SRRW and SR-EV configurations.

The top row are for the SRRW case, and bottom row corresponds to the associated SR-EV configuration. (A) and (E) represent the bonds of the full configurations and show that while SR-EV looks denser than the SRRW case the overall structure is preserved upon removal of the original overlaps. (B) and (F) correspond to the same small portion of the conformation and shows SR-EV having many more beads than SRRW due to the excluded volume between beads. The red circles explicitly highlight a structural motif that in SRRW is a central bead with 7 bonds branching out (a sequence of seven consecutive jump and returns steps) that transform to 15 linearly connecting beads forming a cluster. (C) and (G) display the chromatin conformations wrapped by a tight mesh suggesting the separation between a chromatin rich and a chromatin depleted regions, the latter being the space that free crowders could easily occupy. (D) and (H) show the bare interface between the two regions that resembles the interface dividing two bi-continuous phases and also clearly expose the difference between SRRW and SR-EV.