Fig 2: Sub-modules within enriched modules.
Genes with P < 10−4 are annotated as suggestive. Module enrichment analysis identifies trait-related genes missed by association analysis. (A) Module cma-STRING-104 is enriched for both TG and HDL. APOB is not significant for TG but directly interacts with genes with suggestive or significant p-values for TG. APOB and MSR1 participate in macrophage-derived foam cell differentiation with two genome-wide significant genes (CETP and ABCG1). (B) SYK is not genome-wide significant after CMA. SYK interacts with significant genes for TG, FCER1A and MS4A2, and participates in mast-cell degranulation.