Table 3. Novel BP Loci Identified by the 2df Joint Test, Not Driven by the Interaction Effect.
All results herein are from the M1 model. Supplementary Tables S21–S22 provides summary statistics according to each population group-specific cohort for rs59680540 and rs150586434, and according to each population group for rs34761985 and rs13032423 below. For the sex column, C denotes combined sex meta-analysis. For the alleles column, E denotes effect allele, and O denotes other allele used as reference. Bold denotes significance.
| Exposure | Variant | Nearest gene(s) | Position (hg38) | Alleles (E/O) | Sex | AF | N | Population Groups | Outcome | BM1_G (seM1_G) | BGxE (seGxE) | PM1_G | PGxE | PG,GxE | Psex_diff† |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Loci Identified by 2df Joint Test, Not Driven by Interaction Effect | |||||||||||||||
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| STST | rs59680540* | PRMT6 | 1:106595299 | GGTGA/G | C | 0.0065 | 23897 | HIS | PP | −2.43 (0.66) | −2.59 (1.18) | 2.52E-04 | 2.74E-02 | 4.87E-09 | 4.68E-01 |
| rs34761985* | ST6GAL2 | 2:106923653 | T/TG | C | 0.6124 | 731622 | AFR, EAS, EUR, HIS, SAS | SBP | −0.18 (0.04) | −0.12 (0.08) | 3.87E-06 | 1.43E-01 | 2.87E-09 | 1.10E-01 | |
| rs150586434* | HTR1F | 3:87648138 | A/G | C | 0.0057 | 23902 | HIS | SBP | −3.49 (1.09) | −4.36 (1.77) | 1.40E-03 | 1.37E-02 | 1.31E-09 | ||
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| LTST | rs34761985* | ST6GAL2 | 2:106923653 | T/TG | C | 0.6124 | 731622 | AFR, EAS, EUR, HIS, SAS | SBP | −0.20 (0.04) | −0.06 (0.08) | 7.53E-07 | 4.45E-01 | 4.78E-09 | 1.90E-01 |
| rs13032423* | VRK2 | 2:57764977 | A/G | C | 0.534 | 799211 | AFR, EAS, EUR, HIS, SAS | SBP | −0.21 (0.04) | 0.20 (0.07) | 2.21E-09 | 4.77E-03 | 4.86E-09 | 3.45E-01 | |
*
denotes variants novel for BP.
†
Empty cell in Psex_diff indicates the variant, after quality control, was not found in both sex-stratified meta-analyses.