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[Preprint]. 2024 Mar 8:rs.3.rs-3994894. [Version 1] doi: 10.21203/rs.3.rs-3994894/v1

Figure 4.

Figure 4.

Baseline and post-treatment significantly differentially expressed Conserved Transcriptional Response to Adversity (CTRA) gene counts in peripheral blood mononuclear cell samples measured with nanoString nCounter XT CodeSet custom CTRA gene expression panel. a-g, Effects of dasatinib plus quercetin (D+Q) on the expression of Conserved Transcriptional Response to Adversity (CTRA) gene counts measured in peripheral blood mononuclear cell (PBMC) samples. Seven inflammatory genes were significantly decreased post-treatment. Mean difference (B-statistic): a, FOSB, −218.87 (−0.713); b, PTGS2, −377.76 (−1.177); c, IL-8, −675.93 (−1.215) (d) FOS, −1579.32 (−1.669); (e) IL-1B, −152.94 (−1.922), (f) JUNB, −1267.29 (−3.546) (g) JUN, −505.57 (−3.754). Baseline to post-treatment changes were assessed using two-sided paired sample t-tests, P < 0.05, N = 4, color coded by participant. Paired baseline and post-treatment measures existed for all but one of the participants (blue) for whom only a post-treatment sample was collected. Mean difference = post-treatment - baseline. No correction for multiple comparisons was made due to small sample size.