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. 2024 Feb 27;12:RP87458. doi: 10.7554/eLife.87458

Figure 2. Indole-3-acetate (I3A) administration reverses Western diet (WD)-induced alterations in liver inflammatory cytokines and bile acids.

(A) Inflammatory cytokines in liver tissue at week 16. (B) Liver total bile acid concentration (left panel), and abundance of chenodeoxycholic acid (CDCA) branch bile acids relative to total bile acids pool (right panel). Data shown are mean ± SEM. *: p<0.05, **: p<0.01, ***: p<0.001 using Wilcoxon rank sum test.

Figure 2.

Figure 2—figure supplement 1. I3A supplementation reduces inflammatory cytokines and free fatty acid levels.

Figure 2—figure supplement 1.

(A) Inflammatory cytokines in liver tissue at week 16. (B) Free fatty acids (FFAs) in diet, serum, and liver samples. Data shown are mean ± SEM. **: p<0.01, ***: p<0.001 using Wilcoxon rank sum test.