TABLE 2.
Inhibition of HCMV strains by benzimidazole ribosides
| Virus straina | IC50 (μM)b of:
|
|
|---|---|---|
| BDCRB | TCRB | |
| 1038rA | 6 | NDc |
| 1038rB | 20 | ND |
| 1038rC | 6 | ND |
| 1038rA 5-2-3 | 6 ± 0.6 | ND |
| 1038rB 8-3-3 | 18 ± 5 | >50 |
| 1038rC 4-3-2 | 6 | ND |
| AD169 | 0.6 ± 0.1 | 2.8 |
a
1038rA, -B, and -C are three independently isolated strains. 1038rA 5-2-3, 1038rB 8-3-3, and 1038rC 4-3-2 are the original isolate strains (1038rA, 1038rB, and 1038rC, respectively) plaque purified three times.
b
Results are from a single plaque reduction assay if no standard error is given; otherwise, the results are from at least three assays with the IC50 given as a mean ± standard error.
c
ND, not determined.