TABLE 4.
Sequence comparison of the product of the UL89 exon 2 region carrying BDCRB resistance with ORF products of other herpesviruses
| Virusa | Amino acidsb |
|---|---|
| 1038rB 8-3-3 | E T |
| 1038rA 5-2-3 | E |
| 1038rC 4-3-2 | E |
| rBREK 2-1-4 | T |
| HCMV AD169 | TNTTSDSTCF LTRLNNAPFD MLNVVSYVCE |
| EBV | VNSADQATSF LYKLKDAQER LLNVVSYVCQ |
| HSV-1 | TNTGKASTSF LYNLRGAADE LLNVVTYICD |
| VZV | TNTGKASTSF LYNLRGSSDQ LLNVVTYVCD |
| HHV-6-U | TNSGNHSTSF LMKLNNSPFE MLSVVSYVCE |
| HVS | VNSGDRATSF LFNLKNASEK MLNIVNYICP |
| EHV-1 | TNTGKASTSF LYNLKGAADD LLNVVTYICD |
| BHV-1 | TNTGKASTSF LYNLKGASDG LLNVVTYICN |
| HHV-7 | TNSGNHSTSF LTKLSNSPFE MLTVVSYVCE |
| CONc | tNtgkasTsF LynLkga.d. lLnvVtYvC. |
Abbreviations: HHV-6-U, human herpesvirus 6 (Uganda); HVS, herpesvirus saimiri; EHV-1, equine herpesvirus type 1; BHV-1, bovine herpesvirus type 1; HHV-7, human herpesvirus 7.
The amino acid substitutions at positions 344 and 355 in the sequences of UL89 exon 2 products of 1038rB 8-3-3, 1038rA 5-2-3, 1038rC 4-3-2, and rBREK 2-1-4 are shown aligned above the HCMV AD169 sequence, and the corresponding sequences of other herpesvirus homologs are shown below it.
Consensus sequence for the alignment of HCMV AD169 with the other herpesvirus homologs shown in this table. Capital letters indicate amino acids that are completely conserved, lowercase letters indicate amino acids that are predominantly conserved, and periods indicate limited conservation.