FIGURE 2.

Baseline associations between plasma Aβ42/40 (A), pTau181 (B), NfL (C), GFAP (D), and TabCAT‐BHA cognitive composite (E) with the Clinical Dementia Rating Scale (CDR) Sum of Boxes score. Coefficients of determination are based on multiple linear models covarying for age, female sex, education, and presence of an APOE ε4 allele. Raw values of plasma pTau181, NfL, and GFAP concentrations were natural log‐transformed. Shapes represent clinical syndrome groups (circles = Alzheimer's disease spectrum, triangles = frontotemporal lobar degeneration spectrum, squares = other neurodegenerative syndromes) and colors represent diagnosis groups (red = mild cognitive impairment, teal = dementia, green = subjective cognitive impairment). Aβ, amyloid β; APOE, apolipoprotein E; GFAP, glial fibrillary acidic protein; NfL, neurofilament light; TabCAT‐BHA, Tablet‐based Cognitive Assessment Tool Brain Health Assessment.