FIGURE 3.

Modeled associations of baseline values of plasma pTau181, NfL, GFAP, and TabCAT‐BHA with longitudinal changes on the Clinical Dementia Rating (CDR) Sum of Boxes score. Regression lines are based on the results of linear mixed effect models with random intercepts and slopes in which all markers were simultaneously included as predictors covarying for age, sex, education, presence of APOE ε4 allele, baseline diagnostic group, and years since baseline. Colors represent values one standard deviation below the mean predictor value (red lines), the mean predictor value (blue lines), and one standard deviation above the mean predictor value (green lines). APOE, apolipoprotein E; GFAP, glial fibrillary acidic protein; NfL, neurofilament light; TabCAT‐BHA, Tablet‐based Cognitive Assessment Tool Brain Health Assessment.