TABLE 3.
Results of logistic regression analyses including baseline values of scalable plasma and TabCAT‐BHA markers as predictors, demographic and clinical covariates, and Aβ‐PET status as an outcome (n = 105; 47 Aβ‐PET negative, 58 Aβ‐PET positive).
| β | SE | P‐Value | |
|---|---|---|---|
| Full model (AIC = 61) | |||
| Plasma Aβ42/40 | −94.009 | 47.496 | 0.048 |
| Plasma pTau181 | 2.202 | 0.714 | 0.002 |
| Plasma NfL | −0.081 | 0.034 | 0.017 |
| Plasma GFAP | 0.001 | 0.006 | 0.886 |
| TabCAT‐BHA | −0.827 | 0.368 | 0.025 |
| Age (years) | 0.132 | 0.068 | 0.050 |
| Sex (female) | −0.290 | 1.033 | 0.779 |
| Education (years) | 0.117 | 0.239 | 0.625 |
| APOE ε4 allele | 2.138 | 1.285 | 0.096 |
| PET/Plasma time difference (days) | 0.005 | 0.003 | 0.103 |
| Optimal model (AIC = 63) | |||
| Plasma Aβ42/40 | −94.597 | 34.328 | 0.006 |
| Plasma pTau181 | 2.435 | 0.559 | <0.001 |
| Plasma NfL | −0.088 | 0.031 | 0.005 |
| TabCAT‐BHA | −0.619 | 0.258 | 0.016 |
| Age (years) | 0.079 | 0.046 | 0.085 |
| pTau181, TabCAT‐BHA, age (AIC = 84) | |||
| Plasma pTau181 | 1.977 | 0.432 | <0.001 |
| TabCAT‐BHA | −0.525 | 0.195 | 0.007 |
| Age (years) | 0.054 | 0.037 | 0.139 |
| pTau181, age (AIC = 92) | |||
| Plasma pTau181 | 2.091 | 0.407 | <0.001 |
| Age (years) | 0.019 | 0.031 | 0.527 |
Abbreviations: Aβ‐PET, amyloid β positron emission tomography; AIC, Akaike information criterion; APOE, apolipoprotein E; GFAP, glial fibrillary acidic protein; NfL, neurofilament light; PET, positron emission tomography; SE, standard error; TabCAT‐BHA, Tablet‐based Cognitive Assessment Tool Brain Health Assessment.