TABLE 4.
Results of linear mixed model analyses including baseline values of all scalable plasma and TabCAT‐BHA markers as predictors, demographic and clinical covariates, and Clinical Dementia Rating Scale (CDR) Sum of Boxes as an outcome (n = 185; 32 SCI, 107 MCI, 46 dementia).
| β | SE | df | P | |
|---|---|---|---|---|
| Baseline plasma Aβ42/40 x Years since baseline | 2.060 | 5.937 | 99 | 0.729 |
| Baseline plasma pTau181 x Years since baseline | 0.357 | 0.082 | 103 | <0.001 |
| Baseline plasma NfL x Years since baseline | 0.018 | 0.004 | 90 | <0.001 |
| Baseline plasma GFAP x Years since baseline | −0.002 | 0.001 | 125 | 0.029 |
| Baseline TabCAT‐BHA x Years since baseline | −0.320 | 0.047 | 120 | <0.001 |
| Baseline plasma Aβ42/40 | −0.122 | 8.433 | 159 | 0.149 |
| Baseline plasma pTau181 | −0.128 | 0.117 | 162 | 0.274 |
| Baseline plasma NfL | −0.001 | 0.006 | 157 | 0.876 |
| Baseline plasma GFAP | −0.001 | 0.001 | 165 | 0.658 |
| Baseline TabCAT‐BHA | −0.283 | 0.081 | 166 | <0.001 |
| Age (years; centered) | 0.012 | 0.014 | 163 | 0.397 |
| Sex (female) | 0.163 | 0.228 | 164 | 0.476 |
| Education (years) | 0.025 | 0.037 | 165 | 0.500 |
| APOE ε4 allele | 0.209 | 0.251 | 166 | 0.408 |
| Baseline dementia diagnosis (reference) | – | – | – | – |
| Baseline MCI diagnosis | −3.487 | 0.302 | 165 | <0.001 |
| Baseline SCI diagnosis | −4.832 | 0.431 | 164 | <0.001 |
| Years since baseline | −0.940 | 0.477 | 96 | 0.052 |
Abbreviations: Aβ, amyloid β; APOE, apolipoprotein E; df, degrees of freedom; GFAP, glial fibrillary acidic protein; MCI, mild cognitive impairment; NfL, neurofilament light; SCI, subjective cognitive impairment; SE, standard error; TabCAT‐BHA, Tablet‐based Cognitive Assessment Tool Brain Health Assessment. Degrees of freedom are estimated using Satterthwaite's method.